#gender-affirming-care

Moderna and Merck's individualized cancer vaccine program appears to have overcome years of skepticism, according to STAT. Anthropic's revenue climbed sharply even as its flagship model reportedly loses ground to cheaper rivals, a tension one developer described as forcing harder choices about AI coding costs. Health policy shifted on several fronts: a Medicaid precedent that could reach far beyond its original target, a new FDA nominee, and a promised FDA guidance on generative AI devices.

Z.ai released GLM-5.2, a 753-billion-parameter open-weights LLM under MIT license, which Simon Willison called the most powerful text-only open-weights model available. Separately, a White House report on the Fable 5 export control jailbreak drew pushback from cybersecurity expert Kate Moussouris, who said the restriction harms US cyber defense. OpenAI and Molecule.one published results from a near-autonomous AI chemist using GPT-5.4 that improved a challenging medicinal chemistry reaction. In pharma, nitazene overdose deaths confirmed by the CDC rose from 27 in 2020 to 409 in 2024, while the FTC and four state AGs sued WPATH over its gender-affirming care standards. Tyler Cowen flagged new research showing AI-native startups are organized differently from conventional venture-backed firms, drawing on Y Combinator data from 2020 to 2024.